Evaluate the Efficacy of Bu-Yang- Huan-Wu Tang（BYHWT）on Ischemic Stroke
Status:
Unknown status
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
- Clinical trial; Ischemic stroke; Bu-Yang-Huan-Wu Tang （BYHWT）; Gait parameter; Quality
of life Stroke is the third of ten causing death disease constantly, and it also is
third of consuming healthy insurance budget. There is 17,000 peoples disable due to
stroke every year in Taiwan. Although ischemic stroke patient may use t-PA intravenously
treatment within 3 hrs after stroke onset in modern medicine, and no others method may
effect to treat ischemic stroke patients, thus, the study about stroke is an important
issue. Bu-Yang- Huan-Wu Tang (BYHWT) has been became a main stream for the treatment of
stroke after Qing dynasty Wang Qing-Ren theory that is BYHWT may treat stroke due to
pattern of qi stagnation and blood stasis in traditional Chinese medicine. A number of
researches report that BYHWT can reduce blood viscosity, anti-inflammation, enhancing
neuronal regeneration and angiogenesis, but above-mentioned about BYHWT limit in the
level of animal study and the scientific evidence is insufficiency in human trial.
Therefore, the purpose of the present study was to investigate the therapeutic effect of
BYHWT treating ischemic stroke by using a strict clinical trial.
- We designed a randomized, double blind, placebo-controlled study to assess the
therapeutic effect of BYHWT treating ischemic stroke. The study expects to finish the
assessment of 120 patients with ischemic stroke in three years. The study divided into:
1) control group, receive placebo-BYHWT 3.0 g TID every day for continuously 6 weeks
except ordinary medical care; 2) treatment group, the method is identical control group,
but receive BYHWY. The main outcome was according to the changes of gait parameter
including Speed, Cadence, Strike length, Gait cycle and Double support; and secondary
outcome including the changes of Functional independence measurement scores and Barthel
index scores, Ten Meters Walk Test, Short Physical Performance Batter, Berg Balance Test
and WHO quality of life-brief (Taiwan Brief).
- We predict the results of the present can provide scientific evidence to proof BYHWT can
improve neurological deficit and also can improve quality of life in patients with
ischemic stroke.