Evaluate the Effect of Exenatide Treatment on Coronary Artery Endothelial Function
Status:
Unknown status
Trial end date:
2018-01-01
Target enrollment:
Participant gender:
Summary
Type 2 diabetes mellitus (T2DM) is an important risk factor of cardio-cerebral vascular
disease such as coronary heart disease. GLP-1 is a kind of incretin secreted by the L-cell
located in Ileum. It acts as an incretin hormone by protentiating glucose-stimulated insulin
release. Recent studies reported that GLP-1 RA can protect the vascular endothelial and
prevent vascular from atherosclerosis. Investigators design this study to investigate
exenatide's effect on the improvement of the coronary endothelial function by evaluating
endothelium dependent diastolic function and testing the vascular endothelial active
substance and related inflammatory factors.