Etoricoxib With Flavoxate for Reducing Morphine Requirement After Transurethral Prostatectomy (TURP)

• Status: Completed
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to determine whether etoricoxib, flavoxate, both are effective in the treatment postoperative pain after TURP.

The research hypothesis:

There is a difference in postoperative morphine consumption in the first 24 hours after transurethral prostatectomy between patients who received etoricoxib or flavoxate or both and placebo.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mahidol University
• Treatments: Etoricoxib; Flavoxate; Morphine

Criteria

Inclusion Criteria:

1. Male patient ASA physical status I-III.

2. Scheduled for an elective TURP.

3. Body weight > or = 50 kg

4. Can operate a patient-controlled analgesia (PCA) device.

Exclusion Criteria:

1. History of asthma, acute rhinitis, nasal polyps, angioneurotic edema or urticaria following the administration of aspirin or other NSAIDs.

2. Known hypersensitivity to morphine.

3. History of hepatic dysfunction.

4. Creatinine clearance < 30ml/min.

5. History of bleeding tendency.

6. History of gastrointestinal bleeding or active peptic ulcer.

7. Known case of inflammatory bowel disease.

8. Patient with severe heart failure.

9. History of coronary artery disease or cerebrovascular disease.