Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial

• Status: Completed
• Trial end date: 2020-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients who are having problems breathing sometimes require placement of a breathing tube in their mouth and windpipe. The purpose of this breathing tube is to save the patient's life. It is common to give the patient a medication to sedate him or her before the breathing tube is placed. For patients who are gravely ill two medications are commonly used: etomidate or ketamine. Both medications have risks and benefits. Researchers at UT-Southwestern Medical Center and Parkland Memorial Hospital would like to do a study to figure out which one is better for our patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Texas Southwestern Medical Center
• Treatments: Etomidate; Ketamine

Criteria

Inclusion Criteria:

• Adult patient (male or female) requiring emergency endotracheal intubation.

Exclusion Criteria:

• Children (<18 years old).

• Women who are known to be pregnant.

• Any patient who has been previously randomized in the EvK Trial.

• Patients who require endotracheal intubation without sedative medication. For example, patients in full cardiac arrest.

• Patients with a known allergy to ketamine or etomidate.

• Any individual wearing a MedAlert bracelet indicating that he/she has formally opted out of the EvK Trial.