Etiology, Assessment and Treatment of Post-gastric Bypass Severe Hypoglycemia
Status:
Completed
Trial end date:
2016-03-01
Target enrollment:
Participant gender:
Summary
With increasing rates of obesity the number of anti-obesity operations performed is
increasing; one of the most common is gastric bypass. Anti-obesity surgery ameliorates
diabetes and several other serious comorbidities, but bariatric surgery is also associated
with medical and nutritional complications.
Post-gastric bypass hyperinsulinemic hypoglycemia is a relative rare but serious complication
often seen months to years after gastric bypass surgery. The patients experience
neuroglycopenic symptoms (eg. inability to concentrate, weakness, altered mental status, loss
of consciousness).
The purpose of this study is to determine whether glucagon-like peptide-1 (GLP-1)or other
enteropancreatic factors (eg. gastric emptying rate) are responsible for the excessed insulin
secretion seen in some patients after bariatric surgery.