Ethnic Differences in the Inflammatory Response in Systemic Inflammation

• Status: Completed
• Trial end date: 2006-04-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to investigate putative ethnic differences in the proinflammatory response in human endotoxemia.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Medical University of Vienna

Criteria

Inclusion Criteria:

• Signed informed consent obtained before any trial-related activities. (Trial activities are any procedure that would not have been performed during normal management of the subject).

• Men aged >18 and <40 years

• Normal findings in medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant

• Normal laboratory values unless the investigator considers an abnormality to be clinically irrelevant

Exclusion Criteria:

• Treatment with an investigational drug within three weeks prior to this trial

• Participation in an LPS trial within the last 6 weeks

• Hereditary deficiency of protein C or S, or a mutation of FV (Leiden), or any other known abnormality affecting coagulation, fibrinolysis or platelet function

• History of cardiovascular disease

• Liver or kidney dysfunction

• Regular use of medication or alcohol abuse

• Use of any medication within three weeks prior to the first trial day

• Symptoms of a clinically relevant illness in the 3 weeks before the first trial day

• Excessive sporting activities

• Weight over 95 kg