Estrogen and Perimenopausal Depression

• Status: Completed
• Trial end date: 2004-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

During perimenopause (the time just prior to menopause), women often notice many biological, psychological, and social changes. In particular, some women experience depressive symptoms during perimenopause that are severe enough to warrant antidepressant medication. Whether or not women with perimenopausal depression respond to antidepressant medication may depend on the level of estrogen in their blood. This study will investigate whether estrogen will help women who only partially respond to antidepressant medications, as well as examine how different doses of estrogen may affect individuals differently.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, Los Angeles
• Collaborator: National Alliance for Research on Schizophrenia and Depression
• Treatments: Estrogens

Criteria

Inclusion Criteria:

• Clinical Diagnosis of Unipolar Major Depression, currently taking antidepressants

• HAM-D between 10 and 17

Exclusion Criteria:

• History of Psychosis, breast cancer, smoking, dementia, clotting disorders

• Current substance abuse