The purpose of this research study is to determine if taking a pill of estradiol (E2)
together with prolonged exposure (PE) therapy can improve this treatment outcome in women
diagnosed with Post-Traumatic Stress Disorder (PTSD). 80 subjects will take part in this
research study across NYU Langone Health and UPenn (40 subjects at each site). Participants
will be randomized into one of two groups, PE + E2 or PE + placebo. The study will include
preliminary screening and baseline visits, experimental visits, and therapy visits over the
course of six weeks. Several follow-up visits will take place.