Estrogen Variability and Irritability During the Menopause Transition
Status:
Not yet recruiting
Trial end date:
2024-12-01
Target enrollment:
Participant gender:
Summary
Women in the menopause transition (perimenopause) experience substantial day-to-day
variability in estradiol and have a 2-4-fold increase in major depression risk. About 40% of
perimenopausal women are susceptible to the emergence of affective symptoms tied to changes
in estradiol. Among the perimenopausal women with affective impairment, most report
irritability, not "depression," is their primary source of impairment and distress. The
purpose of this research is to determine the neurophysiologic basis of susceptibility to
estradiol fluctuations and irritability symptoms in perimenopausal women.