Overview Estrogen Therapy as Prevention in the Progression of Aneurysm (EPPA) Trial Status: Withdrawn Trial end date: 2018-12-01 Target enrollment: Participant gender: Summary This study aims to determine if hormone replacement therapy, given during perimenopause may prevent the progression of saccular cerebral aneurysms. Phase: Phase 2 Details Lead Sponsor: Rush University Medical CenterTreatments: EstradiolEstradiol 17 beta-cypionateEstradiol 3-benzoateEstradiol valerateEstrogensPolyestradiol phosphate