Estrogen, Diabetes, and Endothelial Function

• Status: Completed
• Trial end date: 2018-10-22
• Target enrollment: 0
• Participant gender: Female

Summary

This study planned to learn more about women and how the drop in estradiol levels during menopause may affect their cardiovascular risk. With aging, the arteries that are located around the heart get stiffer, and this increase in arterial stiffness can lead to a number of health problems such as high blood pressure and heart disease. In this study, the investigators examined whether a short-term drop in estrogen levels caused arteries to become stiffer, and explored potential reasons for stiffening arteries.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Colorado, Denver
• Treatments: Cetrorelix; Estradiol

Criteria

Inclusion Criteria:

• Premenopausal

• Euthyroid

• Not currently planning to become pregnant

• Not currently breastfeeding

• No recent history of amenorrhea in the previous 6 months

• Consent to data and specimen banking

• No use of hormonal contraceptives

Inclusion Criteria, type 1 diabetes only:

• Diagnosis of type 1 diabetes for at least 5 years

• On insulin within a year of diagnosis

• Current insulin therapy

• Hemoglobin A1c < 9.5%

• No macroalbuminuria (AER < 200 ug/min)

Inclusion Criteria, non-diabetic controls only:

• Hemoglobin A1c < 5.7%

Exclusion Criteria:

• Pregnant and/or breastfeeding

• Have not had a menstrual cycle in the last 6 months