Estradiol-Receptor Blockade in Older Men and Women
Status:
Completed
Trial end date:
2016-05-01
Target enrollment:
Participant gender:
Summary
Repletion of testosterone (Te) in older men drives GH secretion after its aromatization to
estradiol (E2), which acts via the estrogen receptor (ER). Conversely, we postulate that
estrogen deprivation in postmenopausal women attenuates growth hormone (GH) secretion and
insulin-like growth factor-1 (IGF-I) production, thus favoring development of metabolic
syndrome in men treated with toremifene, a new estrogen antagonist used adjunctively in
prostatic cancer