Estimating Apnea Phenotypes From Polysomnography: Oxygen

• Status: Completed
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This study seeks to employ advanced methods to estimate the individual factors contributing to sleep apnea from standard recordings made during routine clinical sleep studies. This study focuses on breathing control or "loop gain" as one of the factors contributing to sleep apnea. Increased levels of oxygen in the air is known to make breathing more stable by lowering "loop gain". Here, our goal is to use a new method capable of detecting a reduction in loop gain with oxygen. The investigators also aim to test whether a high loop gain measured at baseline/placebo predicts a greater improvement in sleep apnea with oxygen therapy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Brigham and Women's Hospital
• Collaborators: American Heart Association; National Heart, Lung, and Blood Institute (NHLBI)

Criteria

Inclusion Criteria:

• Apnea/hypopnea index >20 events per hour

• Age 20-79 years

Exclusion Criteria:

• COPD with desaturation (resting SpO2<96%)

• Use of respiratory stimulants or depressants

• Pregnancy