To investigate the effect of 20 mg esomeprazole daily for one week on gastric emptying of 500
ml beer, the consecutive blood alcohol levels, the gastroesophageal reflux and plasma levels
of gastrin and CCK in a randomized, placebo-controlled, double-blinded manner in 16 healthy
male volunteers.
Hypothesis:
The combined taking of esomeprazole and beer will inhibit gastric emptying as compared to the
intake of beer alone. This will induce a delay of the ethanol absorption and of the
consecutive blood ethanol concentrations. Gastric acid secretion after beer will be reduced
after esomeprazole treatment. Therefore, gastroesophageal acid reflux will be reduced after
the combined taking. We speculate that gastrin, but not CCK plasma levels, will be increased
after the combined taking as compared to beer alone. Both, beer and PPIs, have stimulatory
effects on gastrin release. However, the secretion of CCK from duodenal CCK-cells is
inhibited when gastric emptying is prolonged.