Erythropoetin Neuroprotection for Neonatal Cardiac Surgery
Status:
Completed
Trial end date:
2015-09-01
Target enrollment:
Participant gender:
Summary
Brain problems occur in neonatal open heart surgery with a frequency of 20-70%, seen on
neurological examination, brain imaging such as magnetic resonance imaging (MRI), or long
term development problems such as learning disorders and hyperactivity syndromes. This study
aims to determine if erythropoetin, a natural hormone made in the body, protects the brain
from damage when given in high doses before and during neonatal open heart surgery. We will
use brain MRI, brain wave tests (EEG), neurological examination, and long term developmental
outcome testing to see if erythropoetin is better than salt water injection (placebo) in
protecting the brain.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Baylor College of Medicine
Collaborators:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Texas Children's Hospital The Dana Foundation