Overview

Erlotinib in Combination With Cetuximab

Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
The goal of this clinical research study is to find the highest tolerable dose of Tarceva (erlotinib hydrochloride) that can safely be given in combination with Erbitux (cetuximab). The safety of this drug combination will also be studied.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
M.D. Anderson Cancer Center
Treatments:
Cetuximab
Erlotinib Hydrochloride
Criteria
Inclusion Criteria:

1. Patients with pathologically confirmed advanced or metastatic cancer that is
refractory to standard therapy, relapsed after standard therapy, or who have had no
standard therapy that induces a CR rate of at least 10% or improves survival by at
least three months.

2. Measurable or non-measurable disease.

3. Patients must be >/= 6 wks beyond treatment with a nitrosourea or mitomycin-C, >/= 4
wks beyond other chemotherapy or external beam radiation therapy (XRT), and must have
recovered to prior therapy. (Exception: patients may have received palliative low dose XRT one week
before treatment provided it is not given to the only targeted lesions).

4. (continued from above) Also, patients who have received non-chemotherapeutic
biological agents will need to wait at least 5 half-lives or 4 wks, whichever is
shorter, from the last day of treatment.

5. Eastern Cooperative Oncology Group (ECOG) performance status /= 60%)

6. Patients must have normal organ and marrow function defined as: absolute neutrophil
count >/=1,000/mL; platelets >/=50,000/mL; creatinine (ULN); total bilirubin liver metastasis: total bilirubin
7. Women of childbearing potential and men must agree to use adequate contraception
(hormonal or barrier method of birth control; abstinence) prior to study entry, for
the duration of study participation, and for 30 days after the last dose.

8. Ability to understand and the willingness to sign a written informed consent document

9. For the MTD expansion cohort, patients will be eligible if they meet one of the
following criteria: (I) Have an EGFR-sensitive mutation and have been previously
treated with EGFR inhibitor therapy but have subsequently developed resistance, OR
(II) Have an EGFR-resistant mutation, OR (III) Do not have an EGFR mutation, but have
benefited from EGFR inhibitor therapy (including either >/=4 months of stable disease
[SD] OR a >/= partial response [PR]).

Exclusion Criteria:

1. Patients with uncontrolled concurrent illness, including but not limited to: ongoing
or active infection; altered mental status or psychiatric illness/social situations
that would limit compliance with study requirements and/or obscure study results.

2. Uncontrolled systemic vascular hypertension (systolic blood pressure > 140 mm Hg,
diastolic blood pressure > 90 mm Hg on medication).

3. Patients with clinically significant cardiovascular disease: history of cardiovascular
accident (CVA) within 6 months, myocardial infarction or unstable angina within 6
months, or unstable angina pectoris.

4. Patients with colorectal carcinoma with tumors that demonstrate a Kirsten rat sarcoma
(KRAS) mutation.

5. Pregnant or lactating women.

6. Patients with a history of bone marrow transplant within the previous two years.

7. Patients with a known hypersensitivity to any of the components of the drug products.

8. Patients unable to swallow oral medications or with pre-existing gastrointestinal
disorders that might interfere with proper absorption of oral drugs.

9. Patients with major surgery within 30 days prior to entering the study.