Eradication of Antibiotic-resistant Bacteria Through Antibiotics and Fecal Bacteriotherapy
Status:
Unknown status
Trial end date:
2018-03-01
Target enrollment:
Participant gender:
Summary
This investigator initiated,international, multicenter open-label, randomized controlled
trial aims to assess whether a 5 day course of oral nonabsorbable antibiotics (colistin
sulfate 2 million IU per os 4x/day and neomycin sulfate 500 mg (salt) per os 4x/day )
followed by fecal microbiota transplantation (administered either via nasogastric
administration or via capsules) is effective at eradicating intestinal carriage of
beta-lactamase producing Enterobacteriaceae (ESBL-E) and carbapenemase producing
Enterobacteriaceae (CPE). compared to no intervention (current standard of care) in adult
non-immunosuppressed patients .