Epidural Morphine for Postoperative Analgesia After Total Knee Arthroplasty
Status:
Completed
Trial end date:
2018-05-30
Target enrollment:
Participant gender:
Summary
Single femoral nerve blockade combined with patient-controlled intravenous analgesia are used
for postoperative analgesia for patients after TKA in the hospital of the investigators.
Although this method provides acceptable analgesia, the incidence of opioid-associated side
effects is relatively high. Low-dose epidural morphine is commonly used in postoperative
analgesia after cesarean section, and the effect of single dose morphine lasts more than 20
hours, with low incidences of itching, nausea, vomiting, and respiratory depression. The
investigators hypothesize that, for patients undergoing TKA, the addition of low-dose
epidural morphine to single femoral nerve block and intravenous opioids can improve the
postoperative analgesia, reduce the consumption of intravenous opioids and decrease
opioid-associated side effects.