We propose performing a study in which we compare the effects of bupivacaine and fentanyl
with a different drug combination - bupivacaine and clonidine. The principal research
questions of the study are:
1. To compare the effect of clonidine (with bupivacaine), injected into the epidural space
on the extent of hyperalgesia (abnormal pain/sensitivity in the uninjured skin
surrounding the operation site) in patients undergoing operations for bowel disease,
with that of fentanyl (with bupivacaine).
2. To compare the effect of clonidine (with bupivacaine), injected into the epidural space
on the incidence of chronic pain 6 months after surgery for bowel disease, with that of
fentanyl (with bupivacaine).
Phase:
Phase 3
Details
Lead Sponsor:
Cambridge University Hospitals NHS Foundation Trust