Ephedrine Versus Ondansetron During Cesarean Delivery

• Status: Not yet recruiting
• Trial end date: 2022-03-15
• Target enrollment: 0
• Participant gender: Female

Summary

More than 30% of the patients receiving spinal anesthesia develop hypotension. Hypotension developed during cesarean section (C/S) under spinal anesthesia may jeopardize uteroplacental circulation leading to fetal compromise and even fetal death.

The effect of prophylactic ondansetron on blood pressure after spinal anesthesia has not been compared in a clinical trial with that of a vasoconstrictor. We will compare ephedrine and ondansetron for the prevention of maternal hypotension after spinal anesthesia for elective cesarean delivery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Ephedrine; Ondansetron; Pseudoephedrine

Criteria

Inclusion Criteria:

age >18, <40 years; American Society of Anesthesiologists physical status I or II; term, singleton pregnancy; elective cesarean delivery under spinal anesthesia

Exclusion Criteria:

Patients with a history of diabetes mellitus other than gestational diabetes, hypertension, body mass index >40 kg/m2, complicated pregnancy, allergy to study drugs, long QT syndrome, and/or contraindication to spinal anesthesia were excluded from the study. Patients who required general anesthesia or another drug likely to influence blood pressure before delivery were withdrawn from the study.