Overview

Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors

Status:
RECRUITING
Trial end date:
2032-11-01
Target enrollment:
Participant gender:
Summary
This clinical trial tests how well entrectinib works to treat patients less than 3 years of age with NTRK 1/2/3 or ROS1 fused, high grade glioma or other central nervous system (CNS) tumors.
Phase:
PHASE2
Details
Lead Sponsor:
St. Jude Children's Research Hospital
Collaborator:
Hoffmann-La Roche
Treatments:
Carboplatin
Cyclophosphamide
entrectinib
Etoposide
Filgrastim
Granulocyte Colony-Stimulating Factor
pegfilgrastim
Surgical Procedures, Operative