Enteral Naloxone Versus a Traditional Bowel Regimen for the Prevention of Opioid Induced Constipation in Trauma Patients

• Status: Terminated
• Trial end date: 2012-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if enteral naloxone is more effective than a traditional bowel regimen in the prevention and treatment of constipation and impaired gastric motility in critically ill trauma patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: CAMC Health System
• Treatments: Bismuth subsalicylate; Naloxone

Criteria

Inclusion Criteria:

• Males and non-pregnant females > 18 years of age and < 65 years of age

• MSICU admission to the trauma service at the General Hospital

• Scheduled for continuous infusion/administration of opiate analgesics for at least 24 hours

• Access for enteral administration of medications and tube feeds

• Initiation of tube feeds

Exclusion Criteria:

• NPO

• Pregnancy

• < 18 years of age or > 65 years of age

• Pancreatitis

• Ileus

• Large bowel obstruction present on plain X-ray or CT scan

• Recent intestinal anastomosis (within 2 weeks)

• Section of large bowel removed (within 2 weeks)

• Contraindications to metaclopramide (Reglan) such as parkinson's disease, tardive dyskinesia, etc.

• Traumatic brain injury with a glasgow coma score of at least 8

• Use of pharmacologic paralytics or neuromuscular blockade (NMB)

• Non-english speaking patients