Enteral Glutamine Supplementation for the Patient With Major Torso Trauma

• Status: Terminated
• Trial end date: 2006-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Glutamine is considered a conditionally essential amino acid during critical illness. After severe trauma, glutamine supplementation into the gastrointestinal tract may help maintain bowel function. We hypothesize that for the major torso trauma patient, high dose glutamine given enterally during resuscitation from shock and continued during enteral nutrition support is absorbed, available systemically and preserves gut integrity.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Texas Health Science Center, Houston
• Collaborator: National Institutes of Health (NIH)

Criteria

Inclusion Criteria:

• Adult trauma patients meeting criteria for shock resuscitation

• Major torso trauma

• Admission to the Shock/Trauma Intensive Care Unit

Exclusion Criteria:

• Age <18 years

• Pregnant

• Expected survival < 24 hours

• Bowel in discontinuity

• Renal failure: baseline serum creatinine>3.0 and/or dialysis

• Admission total bilirubin >10 mg/dl

• History of cirrhosis or cirrhosis apparent on exploratory laparotomy

• Asystole or CPR required