Enhancing the Therapeutic Efficacy of Sleep Deprivation by Modafinil
Status:
Withdrawn
Trial end date:
2009-11-01
Target enrollment:
Participant gender:
Summary
The study aims to investigate whether the administration of the stimulant modafinil during a
40 hour sleep deprivation period in depressed patients can intensify the antidepressant
effect of the sleep deprivation as assessed by a reduction in the Hamilton Depression score
(HAMD, 6-item version). We postulate that this also correlates with a reduction of the
polysomnographically assessed overall amount of sleep during this period.