Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease

• Status: Recruiting
• Trial end date: 2022-07-08
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess how alternating-frequency Deep Brain Stimulation (DBS) works to improve postural instability and gait, while also treating other motor symptoms of Parkinson Disease (PD).

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Cleveland Clinic
• Treatments: Dopamine; Dopamine Agonists

Criteria

Inclusion Criteria:

• Bilateral STN DBS for PD

• Medtronic Percept PC implanted DBS battery/pulse generator/recording system

• Presence of balance and/or walking impairment and/or freezing of gait

• Can walk without assistance, OFF meds, based on yes/no verbal response

Exclusion Criteria:

• Severity of gait impairment should not require dependency to walker or cane

• Cannot tolerate monopolar stimulation at either of the two middle electrode contacts (prerequisite for the recording mode of the DBS) at high frequency (130 Hz) or low frequency (60 Hz).

• Concomitant conditions that may affect significantly the evaluation of balance or gait, including orthopedic, rheumatologic or other neurological diseases

• Contraindication to physical therapy

• Age < 21

• Diagnosis of dementia

• Not agreeable to having video taken of entire research visit