Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving
Status:
Completed
Trial end date:
2018-11-05
Target enrollment:
Participant gender:
Summary
The investigators' recently completed study has provided the first evidence that
administration of the medication propranolol, following exposure to cocaine cues, can alter
drug-associated memories and reduce craving and other drug cue-elicited responses in cocaine
addicted persons. The investigators will attempt to augment this effect by a) doubling the
number of propranolol-medicated cocaine cue exposure (CCE) retrieval sessions and b)
increasing the dose of propranolol. It is expected that propranolol treated groups, relative
to placebo treated groups, will evidence greater reduction of craving, cue reactivity and
cocaine use during follow-up cocaine cue exposures. Also, these effects will be greater for
those who receive 80mg of propranolol as opposed to 40mg.