Enhancement of Motor Function With Reboxetine and Transcranial Direct Current Stimulation

• Status: Completed
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The hypothesis of the study is that combination of reboxetine/tDCS is more effective in enhancing motor functions of daily life (assessed by the Jebsen Taylor test) as compared to reboxetine and tDCS alone. The protocol is designed as a within-subject, block randomized placebo-controlled double-blind crossover study.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universitätsklinikum Hamburg-Eppendorf
• Collaborators: German Research Foundation; University Hospital Tuebingen
• Treatments: Reboxetine

Criteria

Inclusion Criteria:

• age between 18 and 86

• patient is contractually capable

• first-ever, ischemic stroke

• minimum time since stroke 9 months

• a paresis of the arm/hand muscles above 3 on the MRC scale

Exclusion Criteria:

• multiple cerebral lesions and associated residual deficits

• severe head trauma in the past

• seizures

• ferromagnetic implants in the head/neck region

• pacemaker

• a psychiatric disorder or neurological disease besides stroke

• intake of illegal drugs

• severe aphasia or cognitive deficits that impede contractual capability

• contraindications for reboxetine (seizures, glaucoma, prostate hyperplasia with urinary retention, cardiac arrhythmias, potential interactions with co-medication)

• pregnancy

• breast-feeding patients