Endovenous Lidocaine and Serum Cytokines Concentration
Status:
Completed
Trial end date:
2014-01-01
Target enrollment:
Participant gender:
Summary
Ineffective treatment of postoperative pain may cause organic damage and chronic pain.
Nevertheless, opioids, the leading drugs used for this purpose, present side effects that
sometimes restrict their usability. In a multimodal context, new postoperative analgesia
techniques have been developed focusing in the reduction of opioid use and their adverse
effects, as well as postoperative chronic pain prevention. In this background, continuous
intravenous infusion of lidocaine during perioperative period has shown to be promising. This
trial aimed to compare postoperative analgesia, opioid consumption, duration of ileus and
length of hospital stay and IL-1, IL-6, IL-10, α TNF and γ IFN levels in patients undergoing
to laparoscopic cholecystectomies who received intravenous lidocaine in comparison to a
control group. Intravenous lidocaine in the perioperative period of laparoscopic
cholecystectomies was not able to reduce postoperative pain, opioid consumption, and duration
of ileus or length of hospital stay. However, its anti-inflammatory effect was evidenced by
the significant changes in the studied cytokines.