Endovascular Treatment and RIPC in Acute Ischemic Stroke
Status:
Recruiting
Trial end date:
2023-02-28
Target enrollment:
Participant gender:
Summary
Endovascular treatment（ET）is an effective therapy for acute ischemic stroke(AIS) with great
vessel obstruction. However, acute complications such as high postoperative perfusion injury,
hemorrhagic transformation and restenosis resulted in functional independence in only about
50% of patients 90 days after interventional surgery. Therefore, it is very important to
protect the neurologic function after emergency endovascular treatment. The investigators'
previous studies have shown that combined with intravenous thrombolytic therapy and remote
postconditioning（RIPC）can significantly improve the neurological impairment and short-term
and long-term prognosis in patients with acute stroke. In this multicenter, randomized
controlled trial, the investigators assumed patients with acute ischemic stroke who had
successfully revascularization after ET might benefit from RIPC as well. Patients in the RIPC
group had five cycles of 5-min cuff inflation followed by 3-min deflation to the bilateral
upper arm after ET. The primary endpoint measure was the proportion of patients with a
favorable recovery of nerve function deficient assessed by Modified Rankin Scale （mRS≤2） 90
days after surgery. Secondary endpoints included the following: (1) Symptom endpoints:
Neurological intelligence and function scores, postoperative hemorrhagic transformation rate,
etc. (2) Blood index test: postoperative inflammatory factors, neuron-specific enolase (NSE)
and other indicators. (3) Imaging endpoints: MRI-FLAIR , TCD, etc.
Phase:
N/A
Details
Lead Sponsor:
First Affiliated Hospital Xi'an Jiaotong University
Collaborators:
Second Affiliated Hospital of Xi'an Jiaotong University Shaanxi Provincial People's Hospital Tang-Du Hospital Xi'an Gaoxin Hospital Xi'an No.3 Hospital Xijing Hospital