Endothelial Hyperpolarization in Humans

• Status: Terminated
• Trial end date: 2013-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to elucidate the role Endothelium-Derived Hyperpolarizing Factor (EDHF) plays in dilating blood vessels and whether it differs between healthy people and those with high cholesterol. A second purpose of the study is to determine the identity of EDHF.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Emory University
• Collaborator: National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Acetylcholine; Bradykinin; Fluconazole; Kininogens; Nitroprusside; omega-N-Methylarginine; Tetraethylammonium

Criteria

Inclusion Criteria:

• Hyperlipidemic (LDL > 140)

• Healthy Volunteer

Exclusion Criteria:

• Pregnancy

• Diabetes mellitus

• Cardiovascular Disease

• Hypertension

• Use of any regular medications

• Renal insufficiency

• Smoking (current or within the past 5 years)

• Bleeding disorder