Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil
Status:
Withdrawn
Trial end date:
2010-02-01
Target enrollment:
Participant gender:
Summary
The investigators would like to study the endothelial function in sickle cell patients
without pulmonary hypertension in an in vivo method during a steady state condition before
and after sildenafil treatment for 1 month, and to study the effects of this nitric oxide
donor by measuring the Flow Mediated Dilatation, by measuring endothelial progenitor stem
cells colonies, and by measuring the effect of therapy on markers of inflammation (cell
adhesion molecules and cytokines).