Overview Endothelial Function in Human Arteries Status: Completed Trial end date: 2011-01-01 Target enrollment: Participant gender: Summary Up to 30 patients with lower extremity disease scheduled to undergo diagnostic angiography will undergo baseline bloodwork and IVUS (intravascular ultrasound), followed by dosing with L-arginine to assess changes in endothelial function. Phase: Early Phase 1 Details Lead Sponsor: The Cleveland ClinicCollaborator: National Institutes of Health (NIH)Treatments: Nitric Oxide