Endothelial Cell Dysfunction in Pulmonary Hypertension
Status:
Completed
Trial end date:
0000-00-00
Target enrollment:
Participant gender:
Summary
This study will examine and test healthy volunteers and patients with pulmonary hypertension
to try to learn more about the disease and find better ways to detect, treat, and, if
possible, slow progression. Pulmonary hypertension is a rare blood vessel disorder of the
lung in which the pressure in the pulmonary artery (the blood vessel that leads from the
heart to the lungs) rises above normal levels and may become life-threatening.
Normal volunteers and patients with pulmonary hypertension 18 years of age and older may be
eligible for this study. All candidates are screened with a review of their medical records.
Normal volunteers also have a medical history, electrocardiogram, echocardiogram (heart
ultrasound), and pulmonary function test, in which the subject breathes in and out of a tube
that measures lung volume, mechanics and function.
All participants undergo the following tests and procedures:
- Echocardiogram to measure heart function and blood pressure in the lungs. A small probe
held against the chest uses sound waves to obtain pictures of the heart.
- Magnetic resonance imaging (MRI) to evaluate the heart's pumping action. Subjects lie
on a stretcher that slides into a long, tube-shaped scanner. The machine uses a
magnetic field and radio waves to obtain images of the heart.
- 6-minute walk to measure how far the subject can walk in 6 minutes. Subjects walk
around the hospital for 6 minutes at a comfortable pace.
- Exercise testing to measure the ability to exercise and the subject's oxygen levels
during exercise. Subjects exercise on a bike or treadmill while the oxygen and carbon
dioxide they breathe are measured using a small device placed in the mouth.
- Right heart catheterization to measure pressure in the heart and lungs. A small
catheter (plastic tube) is placed in an arm vein. A longer catheter called a central
line is placed in a deeper vein in the neck or just below the neck, or in the leg or
arm. A long, thin catheter that measures blood pressure directly is then inserted into
the vein and advanced through the chambers of the heart into the lung artery to measure
all the pressures in the heart and obtain blood samples.
- Genetic and protein studies. DNA, RNA, and proteins from blood samples are studied for
genes and proteins that might predict the development or progression of pulmonary
hypertension.
In addition to the above, patients whose pulmonary hypertension was caused by a blood vessel
injury undergo the tests described below. The right heart catheter inserted for the
catheterization procedure remains in place to obtain measurements of the effects of nitric
oxide and nitrite in the following procedures:
- Inhalation of nitric oxide (a gas naturally produced by cells lining arteries) at
30-minute intervals to examine its effect on lung and heart pressures.
- Inhalation of aerosolized nitrite at 5-minute intervals to measure its effects on lung
and heart pressures.
- Inhalation of nitric oxide for up to 24 hours to obtain multiple measurements of its
effect on lung and heart pressures.
- Blood draws for laboratory tests.
In patients whose pulmonary hypertension was caused by a blood vessel injury, we also plan
to follow response to standard therapy. After the initiation of standard therapy, we will
restudy the same parameters (excluding NO and sodium nitrite studies) in these patients at
approximately 4 months, and yearly for 5 years
Phase:
Phase 1
Details
Lead Sponsor:
National Institutes of Health Clinical Center (CC)