Endoscopic Vital Nerve Staining in Gastrointestinal Diseases

• Status: Not yet recruiting
• Trial end date: 2022-05-15
• Target enrollment: 0
• Participant gender: All

Summary

In this study, methylene blue (MB) was used as vital nerve staining agent. During gastroenteroscopy, mucosal nerve staining was achieved by endoscopic submucosal injection of MB solution. To observe the staining of nerve fibers, neurons and glial cells in mucosa and submucosa, as well as the morphological changes, density differences and function of mucosal nerve tissues in different gastrointestinal lesions, in order to explore the role of endoscopic vital nerve staining in the diagnosis of gastrointestinal lesions.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Affiliated Hospital to Academy of Military Medical Sciences
• Treatments: Methylene Blue; Sodium thiosulfate

Criteria

Inclusion Criteria:

1. Diagnosis or suspected diagnosis of one of the following common gastrointestinal diseases: chronic non-atrophic gastritis, chronic atrophic gastritis, gastric polyps, gastric early cancer, advanced gastric cancer; colonic polyps, colonic Melanosis, early colon cancer, advanced colon cancer

2. Written informed consent

Exclusion Criteria:

1. Those who are allergic to nerve dye components (such as methylene blue, etc.)

2. Complicated with cardiovascular and cerebrovascular diseases, or severely impaired liver, kidney and hematopoietic system.

3. Psychopath

4. There are hemorrhagic diseases

5. Platelet count < 50 × 10 ^ 9 / L

6. Those who are allergic to body mass are

7. Unable to tolerate or cooperate with endoscopy

8. Patients with serious complications, such as severe infection, gastrointestinal bleeding, obstruction and perforation, etc.

9. Pregnant or lactating women