Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis
Status:
Terminated
Trial end date:
2018-01-05
Target enrollment:
Participant gender:
Summary
Management of pharyngoesophageal stenosis (PES) in patients after head and neck cancer (HNC)
treatment remains a challenge. There are some cases of strictures refractory to dilation
sessions. This study aimed to evaluate the efficacy of Mitomycin C (MMC) endoscopic injection
for the treatment of refractory pharyngoesophageal stenosis.
Patients and methods: This is a prospective study in patients with dysphagia following head
and neck cancer treatment, without evidence suggestive of tumor recurrence, and refractory to
endoscopic treatment. Theses undergo endoscopic dilation of the stenotic segment with
thermoplastic bougies, followed by the injection of MMC.