Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis

• Status: Terminated
• Trial end date: 2018-01-05
• Target enrollment: 0
• Participant gender: All

Summary

Management of pharyngoesophageal stenosis (PES) in patients after head and neck cancer (HNC) treatment remains a challenge. There are some cases of strictures refractory to dilation sessions. This study aimed to evaluate the efficacy of Mitomycin C (MMC) endoscopic injection for the treatment of refractory pharyngoesophageal stenosis.

Patients and methods: This is a prospective study in patients with dysphagia following head and neck cancer treatment, without evidence suggestive of tumor recurrence, and refractory to endoscopic treatment. Theses undergo endoscopic dilation of the stenotic segment with thermoplastic bougies, followed by the injection of MMC.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fauze Maluf Filho
• Treatments: Mitomycin; Mitomycins

Criteria

Inclusion Criteria:

• Patients with dysphagia following head and neck cancer treatment

• Patients without endoscopic or radiological evidence suggestive of tumor recurrence

• Patients refractory to endoscopic treatment

Exclusion Criteria:

• Endoscopic or radiological signs suggestive of tumor recurrence