Endometrial Preparation in Frozen Embryo Transfer Cycles
Status:
Recruiting
Trial end date:
2024-12-25
Target enrollment:
Participant gender:
Summary
In order to get optimal pregnancy rates after frozen embryo transfer (FET), the embryo stage
and endometrium should be synchronized. Endometrial preparation is done by either natural,
artificial (Hormonal replacement therapy HRT) , modified natural methods or mild ovarian
stimulation. HRT cycle has a better schedualization however, there are some reports about
higher rates of miscarriage, pregnancy induced hypertension (PIH) and preeclampsia (PET) in
HRT cycles. A recent study has found that incorporation of the aromatase inhibitor
(letrozole) to HRT cycles was associated with better FET outcomes in comparison to hormonal
replacement therapy cycles alone. Meanwhile, mild ovarian stimulation protocol can be done
either by oral drugs like letrozole or by letrozole plus gonadotropins . So this study aims
to compare the reproductive outcomes in two endometrial preparation protocols for frozen
embryo transfer cycles; letrozole mild ovarian stimulation versus HRT plus letrozole
incorporation.