Endometrial Biopsy in Progestin Contraceptive Users
Status:
Not yet recruiting
Trial end date:
2025-11-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to learn more about menstrual changes in progestin contraception
users. We are hoping to find out what changes in the endometrium lead to different bleeding
patterns during the first year of progestin contraception use. Participants will choose to
receive the contraceptive implant (Etonogestrel implant also called Nexplanon) or the
contraceptive injectable (Depo-medroxyprogesterone acetate (DMPA) also called Depo-Provera)
for up to 12 months. They will be asked to have 4 endometrial biopsies over the course of the
study, as well as blood draws, physical exams, and pregnancy tests. Participants will also
use a daily text message or email diary to report bleeding patterns. This study's plan is to
comprehensively phenotype bleeding patterns and profile the entire endometrium using
single-cell RNA seq data (sCRNAseq).