Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism
Status:
Completed
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
Aim 1.Test the hypothesis that activation of the endogenous renin-angiotensin-aldosterone
system impairs glycemic control via effects on insulin sensitivity and insulin secretion.
Aim 2. Test the hypothesis that activation of the endogenous renin-angiotensin-aldosterone
system impairs insulin secretion and insulin sensitivity via an mineralocorticoid-receptor
dependent mechanism.