Endogenous Glucose Production and Acute Sympathetic Blockade
Status:
Not yet recruiting
Trial end date:
2029-12-31
Target enrollment:
Participant gender:
Summary
We will study obese hypertensive subjects in a randomized, crossover study to determine if
two weeks sympathetic blockade improves endogenous glucose production. Subjects will be
studied on 3 different occasions after two weeks of receiving either placebo, amlodipine
(vasodilator arm) or moxonidine (study arm). The order of the studies will be determined
using computer-generated randomization. Patients will be blinded as to which treatment they
are receiving on each day. An investigator blinded to the treatment assignment will perform
the analysis of the data.