Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia
Status:
Completed
Trial end date:
2014-02-01
Target enrollment:
Participant gender:
Summary
Hypotheses:
1. The prevalence of endocrinopathies, and growth hormone (GH) deficiency in particular,
among young children diagnosed with optic nerve hypoplasia (ONH) is higher than is
commonly thought.
2. Early treatment of children with ONH and GH-deficiency can prevent adverse outcomes.
Aims:
1. Determine the prevalence and types of endocrinopathies in children diagnosed with ONH.
2. Correlate endocrine outcome with radiographic, ocular, and developmental findings in
children with ONH.
3. Examine the effect of GH treatment on growth and obesity in children with ONH,
GH-deficiency, and either subnormal or normal growth compared to children with ONH that
are not GH-deficient.
4. Compare growth outcomes between children with isolated GH-deficiency and those with
multiple hormone deficiencies.