Mucopurulent cervicitis (MPC) is a syndrome with associated symptoms including mucopurulent
discharge (mucus and pus) from the cervix and other signs of inflammation such as easily
induced cervical bleeding. The purpose of this study is to evaluate the effectiveness of no
treatment versus empiric treatment with a single dose of cefixime and azithromycin for cure
of MPC. Empiric treatment is the initiation of treatment prior to a firm diagnosis. Study
participants will include 772 women ages 18 and older in good health with MPC. Women will be
randomly assigned to 1 of 2 possible study groups: Group 1 will receive a single dose of
cefixime and azithromycin antibiotics and Group 2 will receive placebo (inactive substance).
Study procedures will include pelvic examination with a cervical swab sample. Participants
will be involved in study related procedures for approximately 2 months, which includes 3
study visits.
Phase:
Phase 3
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)