Elite Sport and Development of Asthma

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

International studies have shown that elite athletes have a high prevalence of respiratory symptoms and asthma as compared to normal subjects. It is unclear whether the increased prevalence of asthma in elite athletes reflects "traditional asthma" or whether it is a special form of "sports asthma". The treatment of elite athletes with asthma seems to vary widely, and only a few studies have focused on the treatment of elite athletes with asthma. Further knowledge of the pathogenesis of sports asthma would lead to a greater understanding and better treatment of the condition. This study will investigate the type of airway inflammation in elite athletes and examine the effect of treatment with inhaled steroids in combination with long-acting beta-agonists versus placebo in the same group.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Bispebjerg Hospital
• Collaborators: Anti Doping Danmark; GlaxoSmithKline; Imperial College London; Ragnhild Ibsens Legat For Medicinsk Forskning; The Research Foundation of Bispebjerg Hospital
• Treatments: Fluticasone Propionate, Salmeterol Xinafoate Drug Combination; Fluticasone-Salmeterol Drug Combination

Criteria

Inclusion Criteria:

• Elite athletes

• Informed consent

• Doctor diagnosed asthma

Exclusion Criteria:

• Current smoker or more than 10 pack-years

• Pregnancy, breast feeding or planning pregnancy during the study.

• ICS within the last 4 weeks prior to visit 1.