Asthma is an inflammatory disease, which means it causes swelling in the lungs to cause
shortness of breath and/or wheezing. There are several asthma medications that help to reduce
this problem.
The objective of this research study is to characterize the presence of electrophilic fatty
acids in the bronchial airway of subjects with controlled asthma at baseline and after
treatment with Aspirin, Indomethacin, or no treatment at all. The presence of electrophilic
fatty acids may indicate inflammation. Aspirin and Indomethacin are known to respectively
increase and inhibit the formation of electrophilic fatty acids. By gaining a better
understanding of how electrophilic fatty acids work and how they respond to different
treatment, researchers hope to be able to find better ways to lessen airway inflammation in
asthma in the future.