Electroencephalographic Profiles During General Anesthesia: a Comparative Study of Remimazolam and Propofol

• Status: Not yet recruiting
• Trial end date: 2023-01-31

Summary

How anesthetic drugs induce and maintain the behavioral state of general anesthesia is an important question in medicine and neuroscience. Different anesthetic drugs act on different molecular targets and neural circuit mechanisms, exhibiting drug-specific EEG features. As a novel ultra-short-acting benzodiazepines drugs, remimazolam has been accepted for induction and maintenance of clinical anesthesia. Compared to the traditional benzodiazepines drugs, remimazolam combines the safety of midazolam with the effectiveness of propofol, and also has the advantages of acting quickly, short half-life, no injection pain, slight respiratory depression, independent of liver and kidney metabolism, long-term infusion without accumulation, and has a specific antagonist: flumazenil. This study aimed to investigate the differences in the characteristics of EEG oscillations during general anesthesia by comparing propofol and remimazolam.

• Phase: N/A

Details

• Lead Sponsor: Second Affiliated Hospital of Nanchang University
• Treatments: Atracurium; Cisatracurium; Dsuvia; Propofol; Sufentanil