Elective Percutaneous Coronary Intervention With or Without Supplemental OXYgen
Status:
Terminated
Trial end date:
2020-08-01
Target enrollment:
Participant gender:
Summary
Supplemental oxygen is frequently used in patients admitted to hospital due to ischemic heart
disease. In the setting of suspected myocardial infarction, clinical practice guidelines
advocate the use of supplementary oxygen even in patients with normal levels of peripheral
oxygen saturation. The theoretical basis for this practice is that an increase in blood
oxygen content may limit ischemia and final myocardial damage and subsequent infarct size.
However, although some experimental laboratory data and small studies in humans have
supported the use of supplemental oxygen in patients with coronary artery disease,
contradicting evidence suggests possible harmful effects, mainly through mechanisms involving
coronary vasoconstriction and reduction of myocardial perfusion (hyperoxemic coronary
vasoconstriction).
In the EPOXY-IMR trial, the investigators aim to further explore possible detrimental effects
from routine use of supplemental oxygen on the coronary circulation with special focus on the
small vessels referred to as the coronary microcirculation.