Efficiency Study of Aspirin to Prevent the Occurrence of Prostate Cancer
Status:
Unknown status
Trial end date:
2019-04-01
Target enrollment:
Participant gender:
Summary
Though the pathogenesis of prostate cancer (PCa) is still obscure, it has been reported, by
investigators previous studies and some other researches, that PCa is often combined with
tissue inflammation which is closely related to prostate specific antigen (PSA) level.
Inflammation could play an important role in the process of occurrence and development of
PCa, however the mechanism is unknown. Inflammatory cytokines could not only mediate
inflammatory reactions, but also participate in the growth, proliferation, invasion and
progression of tumor cells. It has been found that non-steroid anti-inflammatory drugs
(NSAIDs), such as aspirin, can effectively prevent several inflammation related tumor, and
coincidentally, PCa is also closely associated with inflammation. Moreover, latest researches
demonstrated that hormone therapy could induce tissue inflammation in PCa, in which a large
quantity of immune B cells were attracted into the focal and then a lot of cytokines, such as
IKK-β, NF-κB, were released. These cytokines could inhibit apoptosis and promote the growth
of tumor cells, which might be a possible mechanism for long-term inflammatory infiltration
inducing the occurrence of PCa and the transformation to castration-resistant prostate cancer
(CRPC). Based on these proofs, investigators presume it could be possibly an effective way to
prevent the occurrence of PCa and the transformation from androgen-dependent prostate cancer
to CRPC by means of long-term oral aspirin. In this study, investigators intend to explore
the possible effect of anti-inflammatory therapy on the progress of transformations from
inflammation to PCa and from androgen-dependent prostate cancer to CRPC. Investigators plan
to conduct both clinical trials in four groups, including the control group, the NSAIDs
group, the antibiotics group and the NSAIDs+antibiotics group, and a basic experiment in
vitro to assess the effectiveness of anti-inflammatory drugs and elucidate the specific
molecular mechanism.