Introduction: Oral candidiasis is an infectious disease caused by the growth of Candida
colonies and their penetration into oral tissues when physical barriers and host defenses are
weakened. It constitutes one of the most common pathologies within the field covered by
Dentistry. Candida infections are found in at least 80% of AIDS patients and in a third of
HIV infection cases. Systemic diseases such as diabetes and a wide pharmacological arsenal to
which the general population is subjected, are other causes of the increase in the prevalence
of this disease. In addition, the high prevalence of oral sequelae (hyposialia) in the
population over 65 years of age, due to the specific characteristics of this age group, such
as multiple pathologies and drug use, explains the presence of this disease in this segment.
of the population One of the great difficulties for the study of this disease is the
diversity of predisposing factors, which do nothing but throw greater confusion into the
results of the different works.
Objective: To evaluate the reduction/suppression of signs and symptoms of oral candidiasis in
patients treated with head and neck RT, users of Vacucis or Placebo.
Material and method: Patients will receive information regarding the trial and, if they meet
the inclusion criteria and agree to participate in it, they will sign the informed consent.
All patients will be informed following the usual care practice of the characteristics of
their candidiasis infection as well as the possibilities and alternatives of treatment and
their respective efficacy.
A descriptive analysis of the sample in terms of prevalence will be carried out. Categorical
variables will be described as frequency and percentage and continuous variables as mean and
standard deviation or median and interquartile range depending on their adjustment to
normality, which will be calculated with the Kolmogorov-Smirnov test. To study the effect of
the vaccine on the evolution of candidiasis, the Chi-square test, Student's t test or the
non-parametric Mann-Whitney test will be used. The association of prevalence with CFU in both
groups will be analyzed using the ANOVA test. Those values of p < 0.05 will be considered
significant.