Efficacy of Zinc Sulfate With Probiotics for the Treatment of Acute Diarrhea in Children

• Status: Unknown status
• Trial end date: 2012-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Diarrheal disease is one of the major causes of morbidity and mortality in children under five. Disease is treated symptomatically with oral rehydration (ORS) as a basic measure. In children with severe zinc deficiency, diarrhea is common and responds quickly to zinc supplementation. Zinc supplementation may also helpful in diarrheal children without zinc deficiency. Effectiveness of zinc was proven in developing countries but was not in Europe. Objective of our study is to assess whether zinc supplementation given with probiotics and ORS is effective in acute diarrhea in children in Poland.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital No 1 Wroclaw
• Treatments: Zinc; Zinc Sulfate

Criteria

Inclusion Criteria:

• Age 1-36 months

• Acute diarrhea defined as 3 or more watery stools per day

• Informed consent (parents)

Exclusion Criteria:

• Severe dehydration (> 10%)

• Coexisting severe infection (e.g. sepsis, pneumonia, meningitis)

• Immune deficiency

• Chronic digestive tract disease (e.g. celiac diseases, food allergy)

• Antibiotic therapy