Efficacy of XL184 (Cabozantinib) in Advanced Medullary Thyroid Cancer
Status:
Completed
Trial end date:
2020-09-01
Target enrollment:
Participant gender:
Summary
The purpose of this research study is to evaluate the progression-free survival (PFS) with
XL184 as compared with placebo (an inactive substance) in subjects with unresectable, locally
advanced, or metastatic medullary thyroid cancer (MTC). Subjects will be randomized to
receive XL184 or placebo in a 2:1 ratio. XL184 is an investigational drug that inhibits
VEGFR2, MET and RET, kinases implicated in tumor formation, growth and migration.
The Clinical Steering Committee for this study, comprised of study doctors who specialize in
medullary thyroid cancer, has provided guidance regarding the design of the study. The
committee includes: Douglas Ball, MD, Barry Nelkin, PhD, Martin Schlumberger, MD and Steven
Sherman, MD.