Efficacy of Vitamin D Supplementation for Children With Bronchiolitis

• Status: Not yet recruiting
• Trial end date: 2024-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Vitamin D plays an important role in enhancing mucosal immune defense, decreasing excessive inflammation, and increasing mucociliary clearance. Experimental studies have shown that vitamin D reduces inflammation of epithelial cells in airways infected with Respiratory Syncytial Virus and confers antiviral effects. Furthermore, several studies have shown lower serum vitamin D levels in hospitalized children with bronchiolitis. However, studies on the efficacy of Vitamin D supplementation for children with bronchiolitis are scarce with inconsistent findings. In this study, we aim to evaluate the efficacy of vitamin D supplementation in children with bronchiolitis.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sohag University
• Treatments: Cholecalciferol; Vitamin D

Criteria

Inclusion Criteria:

• Age between 3 to 24 months.

• Clinical diagnosis of first episode of bronchiolitis

• First 24 hours of admission.

• Stable or decreasing requirement for oxygen on 2 measurements 2 hours apart.

• Pulse rate less than 180 beat/minute.

• Respiratory rate less than 80 breath/min.

• Oxygen supplementation < 40% Fraction of inspired oxygen or < 2 L/min by nasal prong

• Not on high flow nasal cannula, continuous positive airway pressure, or mechanical ventilation at the time of enrollment.

Exclusion Criteria:

.• History of previous episodes of wheezing.

• History of apnea

• Need for positive pressure support or high flow nasal cannula at the time of enrollment.

• Chronic lung disease (requiring home oxygen, or pulmonary hypertension)

• Cardiac disease (cyanotic, hemodynamically significant [requiring diuretics], or pulmonary hypertension).

• Neuromuscular disease.

• Metabolic disease.

• Immunodeficiency.

• Chromosomal abnormalities.

• Craniofacial malformation

• Hemoglobinopathy.

• Hypercalcemia

• Chromosomal abnormalities

• Use of large doses of vitamin D (> 400 IU/day) in the last month.